Wednesday, February 22, 2006
UCSD Study Shows 'Junk' DNA Has Evolutionary Importance (News + Article)
Contents:
1) UCSD Study Shows 'Junk' DNA Has Evolutionary Importance (Press Release)
Genetic material derisively called "junk" DNA because it does not contain the instructions for protein-coding genes and appears to have little or no function is actually critically important to an organism's evolutionary survival, according to a study conducted by a biologist at UCSD.
In the October 20 issue of Nature, Peter Andolfatto, an assistant professor of biology at UCSD, shows that these non-coding regions play an important role in maintaining an organism's genetic integrity. In his study of the genes from the fruit fly Drosophila melanogaster, he discovered that these regions are strongly affected by natural selection, the evolutionary process that preferentially leads to the survival of organisms and genes best adapted to the environment.
Full text at:
http://ucsdnews.ucsd.edu/newsrel/science/mcjunk.asp
2) Adaptive evolution of non-coding DNA in Drosophila (Article)
A large fraction of eukaryotic genomes consists of DNA that is not translated into protein sequence, and little is known about its functional significance. Here I show that several classes of non-coding DNA in Drosophila are evolving considerably slower than synonymous sites, and yet show an excess of between-species divergence relative to polymorphism when compared with synonymous sites. The former is a hallmark of selective constraint, but the latter is a signature of adaptive evolution, resembling general patterns of protein evolution in Drosophila. I estimate that about 40-70% of nucleotides in intergenic regions, untranslated portions of mature mRNAs (UTRs) and most intronic DNA are evolutionarily constrained relative to synonymous sites. However, I also use an extension to the McDonald-Kreitman test to show that a substantial fraction of the nucleotide divergence in these regions was driven to fixation by positive selection (about 20% for most intronic and intergenic DNA, and 60% for UTRs). On the basis of these observations, I suggest that a large fraction of the non-translated genome is functionally important and subject to both purifying selection and adaptive evolution. These results imply that, although positive selection is clearly an important facet of protein evolution, adaptive changes to non-coding DNA might have been considerably more common in the evolution of D. melanogaster.
Full text at:
http://www.euchromatin.com/Andolfatto01.htm
PDF versions:
http://evogen.bio.uci.edu/JC_PDFs/flygenomearticle.pdf
http://eebweb.arizona.edu/Courses/Ecol426_526/Andolfatto_2005.pdf
John Latter
Model of an Internal Evolutionary Mechanism
http://members.aol.com/jorolat/index.html
1) UCSD Study Shows 'Junk' DNA Has Evolutionary Importance (Press Release)
Genetic material derisively called "junk" DNA because it does not contain the instructions for protein-coding genes and appears to have little or no function is actually critically important to an organism's evolutionary survival, according to a study conducted by a biologist at UCSD.
In the October 20 issue of Nature, Peter Andolfatto, an assistant professor of biology at UCSD, shows that these non-coding regions play an important role in maintaining an organism's genetic integrity. In his study of the genes from the fruit fly Drosophila melanogaster, he discovered that these regions are strongly affected by natural selection, the evolutionary process that preferentially leads to the survival of organisms and genes best adapted to the environment.
Full text at:
http://ucsdnews.ucsd.edu/newsrel/science/mcjunk.asp
2) Adaptive evolution of non-coding DNA in Drosophila (Article)
A large fraction of eukaryotic genomes consists of DNA that is not translated into protein sequence, and little is known about its functional significance. Here I show that several classes of non-coding DNA in Drosophila are evolving considerably slower than synonymous sites, and yet show an excess of between-species divergence relative to polymorphism when compared with synonymous sites. The former is a hallmark of selective constraint, but the latter is a signature of adaptive evolution, resembling general patterns of protein evolution in Drosophila. I estimate that about 40-70% of nucleotides in intergenic regions, untranslated portions of mature mRNAs (UTRs) and most intronic DNA are evolutionarily constrained relative to synonymous sites. However, I also use an extension to the McDonald-Kreitman test to show that a substantial fraction of the nucleotide divergence in these regions was driven to fixation by positive selection (about 20% for most intronic and intergenic DNA, and 60% for UTRs). On the basis of these observations, I suggest that a large fraction of the non-translated genome is functionally important and subject to both purifying selection and adaptive evolution. These results imply that, although positive selection is clearly an important facet of protein evolution, adaptive changes to non-coding DNA might have been considerably more common in the evolution of D. melanogaster.
Full text at:
http://www.euchromatin.com/Andolfatto01.htm
PDF versions:
http://evogen.bio.uci.edu/JC_PDFs/flygenomearticle.pdf
http://eebweb.arizona.edu/Courses/Ecol426_526/Andolfatto_2005.pdf
John Latter
Model of an Internal Evolutionary Mechanism
http://members.aol.com/jorolat/index.html
technorati tags: junk, dna, evolutionary, protein, organism, survival, nature, genes, fruit+fly, natural+selection, adaptive, evolution, genome, environment, eukaryotic
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For "Junk DNA" see the hub:
http://www.junkdna.com and its news
http://www.junkdna.com/new_citations.html
For an algorithmic approach, see
http://www.fractogene.com
For PostGenetics, see
http://www.postgenetics.org
Dr. Andras J. Pellionisz
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http://www.junkdna.com and its news
http://www.junkdna.com/new_citations.html
For an algorithmic approach, see
http://www.fractogene.com
For PostGenetics, see
http://www.postgenetics.org
Dr. Andras J. Pellionisz
<< 'Main Blog' Home
